XPO1 inhibition has the potential to engage the cell’s innate ability to fight cancer1-5

The impact of XPO1 inhibition has been shown in two tumor types—and is under investigation in several others.3-6

It moves cellular factors out of the cell nucleus

XPO1 is a nuclear export protein responsible for the transport of cargoes between the cell nucleus and cytoplasm.7-12 Some of these cargoes can be associated with hallmarks of cancer.11-13

It can also affect other ways cells normally fight some cancers

Dysregulated XPO1 can also help cancer cells evade detection and thrive by impacting a range of factors that normally help suppress cancer.6,11-15

Karyopharm is committed to continued research into the promise and potential of XPO1 inhibition in several hematologic and solid tumors.3-5

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  1. Das A, et al. Exp Hematol Oncol. 2015;4:7. doi:10.1186/s40164-015-0002-5.
  2. Gandhi UH, et al. Clin Lymphoma Myeloma Leuk. 2018;18(5):335-345. doi:10.1016/j.clml.2018.03.003.
  3. ClinicalTrials.gov Identifier: NCT02649790. https://clinicaltrials.gov/ct2/show/NCT02649790. Accessed November 28, 2023.
  4. ClinicalTrials.gov Identifier: NCT05611931. https://clinicaltrials.gov/ct2/show/NCT05611931. Accessed November 28, 2023.
  5. ClinicalTrials.gov Identifier: NCT04562389. https://clinicaltrials.gov/ct2/show/NCT04562389. Accessed November 28, 2023.
  6. Azizian NG, et al. J Hematol Oncol. 2020;13(1):61. doi:10.1186/s13045-020-00903-4.
  7. Fornerod M, et al. Cell. 1997;90(6):1051-1060. doi:10.1016/s0092-8674(00)80371-2.
  8. Dong X, et al. Nature. 2009;458(7242):1136-1141. doi:10.1038/nature07975.
  9. Stade K, et al. Cell. 1997;90(6):1041-1050. doi:10.1016/s0092-8674(00)80370-0.
  10. Taylor J, et al. Cancer Discov. 2019;9(10):1452-1467. doi:10.1158/2159-8290.CD-19-0298.
  11. Sun Q, et al. Signal Transduct Target Ther. 2016;1:16010. doi:10.1038/sigtrans.2016.10.
  12. Azmi AS, et al. Nat Rev Clin Oncol. 2021;18:152-169. doi:10.1038/s41571-020-00442-4.
  13. Balasubramanian SK, et al. Leukemia. 2022;36:601-612. doi:10.1038/s41375-021-01483-z.
  14. Culjkovic-Kraljacic B, et al. Cell Rep. 2012;2(2):207-215. doi:10.1016/j.celrep.2012.07.007.
  15. Zhao L, et al. Transl Cancer Res. 2021;10(11):4664-4679. doi:10.21037/tcr-21-1646.
Woman studying test tube