Work Fit for Life. Boundless Opportunity.

If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That’s why we’ve built an environment centered around support, flexibility, and a shared mission.

Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us – whether that’s onsite, from home, or anywhere in between.

What do you get when you pair an extraordinary mission with a culture of flexibility and empowerment? We invite you to find out and join us on this incredible mission.


Our Blueprint for Success

At Karyopharm we live by our ICARE values in order to provide access to novel therapies and ongoing support to patients living with cancer. This common value proposition allows us to work collaboratively, efficiently, and in sync as a global team with a singular focus on treatments that change lives.

  • Innovation

    We challenge the status quo when the current thinking no longer provides the best solution for our patients. We innovate with purpose and draw from diverse experiences.

  • Courage

    We pursue excellence and empower our collaborative teams to speak the truth and act boldly and compliantly with integrity, as we set and exceed clear and ambitious expectations.

  • Alignment & Accountability

    Together as One Karyopharm we deliver results that support a culture of networked teams that work together and drive results in service of patients.

  • Resilience

    We prioritize a culture of adaptability. Our teams not only celebrate successes, but also overcome obstacles and move forward.

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    We approach our work with passion and dedication.

Our Statement on Diversity, Equity, and Inclusion

Karyopharm is committed to improving the lives of patients and those who love them by developing novel therapies to treat cancer and other rare diseases. The work we do is both inspiring and life-changing.  It requires the most diverse, the most unique, and the most authentic team in the industry. We are so proud of our global team who bring their broad range of expertise, experiences, languages, and backgrounds with them every day to do the work that is so clearly their passion. We are committed to diversity, equity, inclusion and belonging. We celebrate all forms of diversity (e.g. gender, gender identity, race, ethnicity, national origin, sexual orientation, differently-abled, veterans and so much more). It is our firm belief that this is a part of our strength and makes us uniquely suited to succeed in our ongoing commitment to employees, physicians, patients, and families alike.

Our Statement on Equal Employment Opportunity

Karyopharm Therapeutics Inc. (the “Company”) is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department.

Why work with us

Shijie VP, Data Sciences – Biostatistics

As the VP of Data Sciences, the role of my team and of myself is to advance Karyopharm drug discovery and development programs by utilizing our knowledge in data. Throughout my four years at the company, I have been able to work on all of our clinical studies and regulatory submissions. These types of opportunities to help patients with unmet medical needs makes me realize that my work is so meaningful and so important.

Monique Associate Director Field Excellence

I’ve always been inspired by work that makes a significant impact in patients’ lives, and Karyopharm provided that opportunity. Right away it was clear to me that the company’s commitment to patients and dedication to its ICARE values would continue to motivate me. Our ICARE values are not just words – they are ingrained into our daily work, help me to foster a culture that values everyone’s input, drive exceptional results, and consistently exceed expectations. Working at Karyopharm is fulfilling; it means being part of a passionate, hardworking team striving to bring much-needed cancer treatments to those waiting.

Stephanie Senior Executive Assistant, R&D

I was excited to join a company with a mission to help patients, and liked the small business feel combined with a rapidly growing vision for the future. Cancer touches all of our lives, and I am inspired daily to work towards a treatment for all kinds of cancer at every stage. I am proud to be working for a company that is doing this work in the world.

Jenna Senior Oncology/Hematology Sales Specialist

I’ve been with Karyopharm since our first commercial launch. The opportunity to join at that time was a true trifecta – to launch a new company, a new medication, and an entirely new class of medicine. Since 2019, I have enjoyed being the local contact and face of Karyopharm/XPOVIO for a wide range of HCPs who would like to learn more about XPOVIO. Along with all my Hematology Oncology Specialist (HOS) colleagues, I strive to provide education and support that allows appropriate patients to have the best outcome on XPOVIO. Every day I have the unique opportunity to provide hope to patients with cancer. 
I feel very fortunate to be able to spread that message to HCPs who directly impact patients’ lives.

Lisa Senior Manager, GMSA Operations

What drives me every day is being part of a company that’s at the forefront of finding, creating, and bringing new medicines to the world, all while putting the patient right at the heart of our mission. 
In my work in congress planning, I have the privilege of working alongside like-minded colleagues across the company who are dedicated to our mission. Together we innovate and produce creative solutions to disseminate our data at scientific meetings and congresses – all to help get our story out to the healthcare community, and ultimately, patients. It’s an exciting time to be a part of the journey here.

  • Health Benefits

    Peace of mind through best-in-class medical, dental, and vision benefits as well as the latest in Telemedicine and Virtual Reality.

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  • Supporting ALL Families,
    ALL the Time

    We support families from diverse backgrounds and structures, offering benefits such as employee-paid Life and AD&D insurance for both employees and dependents. Additionally, we offer short-term disability, long-term disability, and parental leave to provide assistance during significant life events.

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  • Embrace Your Wellness

    Employees and Families have a range of needs and Karyopharm works to provide support in the form of fitness reimbursement, mindfulness programs, exercise classes and mental health programs.

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  • Partner in Prosperity

    Karyopharm offers a competitive 401k match with an immediate vest, an Employee Stock Purchase Program offering a 15% discount, and a total rewards program that includes programs for all employees at all stages of their careers

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Lets Talk

Like what you see but still have some questions about careers at Karyopharm? Click below for answers. We’re happy to put you in touch with the right person on the Karyopharm team to get the information that would be helpful.