Close up of microscope and test sample

Supporting Medical Research

Karyopharm is committed to supporting independent research, globally, as part of the development process for Karyopharm investigational drug candidates. Independent research may be defined within the industry as Investigator Sponsored Research (ISR), Investigator Initiated Research (IIR), Investigator Sponsored Trials (IST) or Investigator Initiated Trials (IIT) and Outcomes Research (OR). 

Karyopharm considers all independent research to be part of its Global Medical Research (GMR) program. 

How to Get Started

Investigators from the scientific and academic research communities may submit a proposal for Global Medical Research (GMR) through our online portal called PORE®. Karyopharm may provide support of independent research in the form of drug supply only or drug supply with funding. This program is open to physicians, researchers and institutions interested in conducting independent research.

Researchers interested in Karyopharm’s GMR program are required to first contact the Karyopharm team to initiate a preliminary discussion of their research proposal. Submit a request

After your preliminary discussion with Karyopharm, we welcome you to formally submit your request via our PORE® Request Management System

How the Review Process Works

Through the Karyopharm internal review process, independent and unsolicited research proposals are periodically reviewed for scientific merit and alignment with our clinical development strategy, among other factors.

Karyopharm strives to provide a response to your application within 45 days of submission to PORE®. If, after internal review, the proposal is endorsed, we expect the applicant to provide a well-designed protocol to be submitted within 60 days of endorsement while supporting a rapid contracting process aiming to achieve start-up within 180 days of endorsement.

Additional information regarding the submission requirements can be found within PORE®. You may also submit any further GMR related questions to

Submission of a proposal does not imply nor guarantee endorsement. Any support of a proposal to be provided by Karyopharm is contingent upon an executed research agreement and the terms therein.

Woman studying test tube