Mr. Greene has served as a member of our Board of Directors since January 2013 and as our Lead Independent Director since January 2015. Mr. Greene has served as Chief Executive Officer of Sage Therapeutics since December 2020. Mr. Greene served as President of Alnylam Pharmaceuticals, Inc., from 2007 to September 2020, and as its Chief Operating Officer from 2003 to 2016. Prior to his 17 year tenure at Alnylam, Mr. Greene was General Manager of Oncology at Millennium Pharmaceuticals, Inc., where he led the company’s global strategy and execution for its oncology business, including strategic business direction and execution, culminating in the successful U.S. Food and Drug Administration approval and launch of VELCADE ® (bortezomib) in 2003. Prior to joining Millennium in 2001, Mr. Greene served as Executive Vice President and Chief Business Officer for Mediconsult.com, a healthcare consulting company. Prior to Mediconsult.com, Mr. Greene’s experience included serving as Vice President of Marketing and Customer Services for AstraZeneca (formerly AstraMerck), Vice President, Strategic Integration with responsibility for the AstraZeneca North American post-merger integration; and a partner of Andersen Consulting, a consulting company, where he was responsible for the pharmaceutical/biotechnology marketing and sales practice. Mr. Greene has served as a member of the board of directors of Sage Therapeutics since October 2020 and has served as a member of the board of directors of Acorda Therapeutics, Inc., since 2007, where he also serves as a member of its compensation committee. Mr. Greene received his B.S. in Industrial Engineering from the University of Pittsburgh and served as a Senior Scholar at Duke University’s Fuqua School of Business.