Cathy Eng, MD, FACP, FASCO
Professor of Medicine, Hematology and Oncology, and Co-Director of GI Oncology and Co-Leader of the Gastrointestinal Cancer Research Program at the Vanderbilt-Ingram Cancer Center
Dr. Eng is a national and international leader in gastrointestinal medical oncology and the David H. Johnson Chair in Surgical and Medical Oncology at the Vanderbilt-Ingram Cancer Center. She joined the faculty at Vanderbilt-Ingram Cancer Center in July 2019 after over 17 years at the MD Anderson Cancer Center. Her primary clinical research interests include clinical trials involving innovative drugs for the treatment of colorectal, anal, and appendiceal cancers. She has a specific interest in young colorectal cancer patients as well as the role of immunotherapy in HPV-associated cancers. She has published multiple publications in these GI malignancies.
Nationally, Dr. Eng has served in multiple leadership roles for ASCO, ASCO GI, ECOG, and the NCI Rectal/Anal Task Force. She has most recently been chosen to serve as the Vice-Chair for the SWOG GI Committee and the NCI GI Steering Committee.
Dr. Eng received her medical degree from Hahnemann University School of Medicine in Philadelphia. She completed residency in internal medicine at Rush University Medical Center and a fellowship in hematology and oncology at University of Chicago Medical Center.
Andrew Kung, MD, PhD
Pediatric Oncologist and Chair, Department of Pediatrics at Memorial Sloan Kettering Cancer Center
Dr. Kung is a physician-scientist and Chair of the Department of Pediatrics at Memorial Sloan Kettering. He oversees the clinical, research, and educational missions of the department and MSK Kids. He specializes in caring for patients using cancer genomics (studying the genetic changes related to cancer), precision medicine (tailoring treatment to the biology of the disease), and stem cell transplantation. In his research, Dr. Kung focuses on identifying the causes of pediatric cancers and developing new treatments to benefit children and teens with these diseases.
Dr. Kung received his medical degree from Stanford University School of Medicine. He completed residency in pediatrics at Children’s Hospital Boston and a fellowship in pediatric hematology/oncology at Children’s Hospital Boston/Dana-Farber Cancer Institute.
Andrew Lassman, MD
John Harris Associate Professor of Neurology and the Chief of Neuro-oncology at Columbia University Irving Medical Center and the Associate Director for Clinical Trials at the Herbert Irving Comprehensive Cancer Center
Dr. Lassman is a neuro-oncologist whose research and clinical efforts focus on improving the understanding and treatment of brain tumors. Specifically, his research interests focus on translational clinical trials for brain tumors with molecular correlative analyses to understand the reasons for treatment success or failure, and to refine treatment paradigms. Dr. Lassman has led retrospective studies, single institution prospective clinical trials, and multicenter prospective trials conducted nationally through the National Cancer Institute sponsored National Clinical Trials Network. His contributions to the field of neuro-oncology has been recognized with numerous awards, including the Preuss Award in Neuro-Oncology from the American Academy of Neurology, the Boyer Clinical Research Award from Memorial Sloan-Kettering Cancer Center, and the Gary Lichtenstein Humanitarian Award from Voices Against Brain Cancer.
Dr. Lassman earned his BS and MS degrees in Molecular Biophysics and Biochemistry as part of a combined 4-year program at Yale University, and went on to receive his MD from Columbia University College of Physicians and Surgeons. Dr. Lassman subsequently completed his residency at the Neurological Institute of New York-Presbyterian Hospital/Columbia University Irving Medical Center, and fellowship in Neuro-Oncology at Memorial Sloan-Kettering Cancer Center, where he then joined the faculty and served as fellowship director.
Mansoor Raza Mirza, MD
Chief Oncologist at the Department of Oncology, Rigshopitalet – Copenhagen University Hospital, Denmark
Dr. Mirza has served as a member of our board of directors since October 2010. He has also served as a scientific consultant to us since 2010. Dr. Mirza is Chief Oncologist at the Department of Oncology, Rigshopitalet — the Copenhagen University Hospital, Denmark and Medical Director of Nordic Society of Gynaecological Oncology (NSGO).
Dr. Mirza is both a medical and radiation oncologist, with a primary focus in non-surgical treatment of gynecologic cancers. His key academic goals are to promote clinical research, international trial collaboration and education, and he has broad experience in clinical protocol development, trial conduct and clinical trial regulations.
Dr. Mirza is the author of several phase 1, 2 and 3 studies and serves as the chair of the Independent Data Safety Monitoring Committee of the OUTBACK trial, which is a large international cervical cancer trial. He is the senior author of national Danish guidelines for the management of endometrial, cervical, vulvar and non-epithelial ovarian cancers as well as of NSGO radio therapy guidelines for cervical and vulvar cancers.
His other current appointments include service as ESGO Council Member (European Society of Gynaecological Oncology), Executive Director of GCIG (Gynecologic Cancer InterGroup), Vice-Chairman of the Danish Gynecological Cancer Society, Founding Executive Member of the European Network of Gynecologic Oncology Trials Group and faculty member of the European Society of Medical Oncology and of the International Gynecologic Cancer Society. He also serves on the board of directors of Sera Prognostics, Inc., a private biopharmaceutical company.
He holds a M.D., Diploma in Surgery and Diploma in Clinical Oncology from the Pirogov Moscow State Medical Institute as well as post-graduate education and certification in radiation and medical oncology from the University of Southern Denmark.
Michael Savona, MD, FACP
Associate Professor of Internal Medicine, and Director of Early Therapeutics, Hematologic Malignancies at Vanderbilt University
Dr. Savona is currently Associate Professor of Internal Medicine, and Director of Early Therapeutics, Hematologic Malignancies at Vanderbilt University.
He recently served as Director, Leukemia Research, at Sarah Cannon Research Institute where he spearheaded efforts to develop a Phase I program in Hematology.
He has been the Principal Investigator on dozens of clinical studies, and has been the lead investigator on studies of variety of novel compounds in hematologic malignancies. He has been involved medical research for 20 years, and has published extensively in major academic journals including Nature Medicine, Blood, Cell Stem Cell, JAMA, and Nature Cancer Reviews.
He is board certified in medical oncology, hematology and internal medicine, and is an elected fellow of the American College of Physicians. Dr. Savona obtained his bachelor’s degree in philosophy from Davidson College and medical degree at Wake Forest University School of Medicine in Winston-Salem, North Carolina.
Sharon Shacham, PhD, MBA
Co-Founder, Chief Scientific Officer
Dr. Shacham co-founded Karyopharm in 2008 and has served as our Chief Scientific Officer since December 2012. She was also President of Research and Development from December 2012 to April 2021. From 2010 to 2012, Dr. Shacham served as our Chief Scientific Officer and Head of Research and Development, and prior to that, as our President and Chief Executive Officer. Dr. Shacham has led our scientific progress since inception.
Prior to joining Karyopharm, Dr. Shacham served as Senior Vice President of Drug Development at Epix Pharmaceuticals, Inc., and Director, Algorithm and Software Development at Predix Pharmaceuticals Inc., which merged into Epix Pharmaceuticals in 2006, and where she led the company’s efforts in GPCR modeling, computational chemistry, lead optimization and development of clinical trials.
Dr. Shacham holds a Bachelor of Science in Chemistry, a Doctor of Philosophy in Chemistry, and a Master of Business of Administration from Tel Aviv University.